To maintain compatibility with OLE 1, you must include specific OLE 1 information. The "server" key entry should contain a full path to the application. The entries for verbs must start with 0 as the primary verb and be consecutively numbered.
Hkey_Classes_Root\Ole2isvrotl\Protocol\Stdfileediting\Server =
C:\Samp\Isvrotl.Exe
Hkey_Classes_Root\Ole2isvrotl\Protocol\Stdfileediting\Verb\0 = &Edit
Hkey_Classes_Root\Ole2isvrotl\Protocol\Stdfileediting\Verb\1 = &Open