You create a new ReplicationRoute object by calling the ReplicationServer.AddRoute method, as in the following example, where ReplRoute is the name you give to the new ReplicationRoute object:
Option Explicit
On Error Resume Next
dim ReplServer
set ReplServer = CreateObject("CrsApi.ReplicationServer")
ReplServer.Initialize("")
dim ReplRoute
set ReplRoute = ReplServer.AddRoute("Default")
...
'Release objects
set ReplRoute = Nothing
set ReplServer = Nothing