This example finds all cells in the range A1:A500 that contain the value 2 and makes those cells gray.
With Worksheets(1).Range("a1:a500")
Set c = .Find(2, lookin:=xlValues)
If Not c Is Nothing Then
firstAddress = c.Address
Do
c.Interior.Pattern = xlPatternGray50
Set c = .FindNext(c)
Loop While Not c Is Nothing And c.Address <> firstAddress
End If
End With